Feature Acyclovir Docosanol (Abreva) Type Antiviral Barrier cream Mechanism Stops viral DNA replication Blocks virus entry into cells Best Stage Early + late stage Early (tingling stage) Strength Strong (prescription) Mild–moderate (OTC) Access Prescription Over-the-counter Best For Severe/recurrent outbreaks First signs of cold sore If you’ve ever felt that early tingling on your lip, you… Continue reading Acyclovir vs Abreva (Docosanol): Which Cold Sore Treatment Works Faster—Prescription or OTC?